Exploring the effect of sialic acid orientation on ligand–receptor interactions

Abstract

Here, we present the synthesis of two sialo-micelles to validate the significance of sialic acid orientation during specific carbohydrate–protein and carbohydrate–carbohydrate interactions. Our data clearly suggest that orientation of carboxylic acid and glycerol side chains of sialic acid moieties exert fine tuning of ligand–receptor interactions.