Transition-Metal-Free CH Hydroxylation of Carbonyl Compounds
| dc.contributor.author | CHAUDHARI, MORESHWAR B. | en_US |
| dc.contributor.author | Sutar, Yogesh | en_US |
| dc.contributor.author | MALPATHAK, SHREYAS | en_US |
| dc.contributor.author | HAZRA, ANIRBAN | en_US |
| dc.contributor.author | GNANAPRAKASAM, BOOPATHY | en_US |
| dc.contributor.department | Dept. of Chemistry | en_US |
| dc.date.accessioned | 2019-07-01T05:34:34Z | |
| dc.date.available | 2019-07-01T05:34:34Z | |
| dc.date.issued | 2017-07 | en_US |
| dc.description.abstract | Transition metal and reductant free ?-C(sp3)-H hydroxylation of carbonyl compounds are reported. This method is promoted by commercially available inexpensive KO-t-Bu and atmospheric air as an oxidant at room temperature. This unified strategy is also very facile for hydroxylation of various carbonyl compound derivatives to obtain quaternary hydroxyl compounds in excellent yield. A preliminary mechanistic investigation, supported by isotope labeling and computational studies, suggests the formation of a peroxide bond and its cleavage by in situ generated enolate. | en_US |
| dc.identifier.citation | Organic Letters, 19 (13), 3628-3631. | en_US |
| dc.identifier.issn | 1523-7060 | en_US |
| dc.identifier.issn | 1523-7052 | en_US |
| dc.identifier.sourcetitle | Organic Letters | en_US |
| dc.identifier.uri | http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/3242 | |
| dc.identifier.uri | https://doi.org/10.1021/acs.orglett.7b01616 | |
| dc.language.iso | en | en_US |
| dc.publication.originofpublisher | Foreign | en_US |
| dc.publisher | American Chemical Society | en_US |
| dc.subject | Transition-Metal-Free | en_US |
| dc.subject | C-H Hydroxylation | en_US |
| dc.subject | Carbonyl Compounds | en_US |
| dc.subject | Hydrocarbons | en_US |
| dc.subject | Organic synthesis | en_US |
| dc.subject | 2017 | en_US |
| dc.title | Transition-Metal-Free CH Hydroxylation of Carbonyl Compounds | en_US |
| dc.type | Article | en_US |