Silver Assisted Gold-Catalyzed Synthesisof Glyco-Calix[4]arenes

Abstract

In this study, glycosylation of calix[4]arenes was explored utilizing silver-assisted gold- catalyzed conditions. We have optimized reaction conditions for higher yields and selectivity. Alkynyl glycosyl carbonate donors were used due to their stability and efficiency. [Au]/[Ag]-catalysis enabled regio- and stereoselective glycosylation under mild conditions, avoiding the drawbacks of acid-based methods. Thus synthesized glycosylated calix[4]arenes would improve the solubility and bioactivity, making them promising candidates for further biomedical applications. These findings provide a sustainable and effective approach for carbohydrate-based molecular modifications.