Propargyl 1,2-orthoesters for stereoselective synthesis of thioglycosides and 1-thiotrehaloses

Abstract

Various thiosaccharides and 1-thiotrehaloses were synthesized exploiting salient features of gold-catalyzed glycosidation repertoire using alkynyl 1,2-orthoesters as glycosyl donors. The reaction was found to be general, high yielding, diastereoselective, fast, mild and catalytic.