Carbonohydrazonoyl dicyanide-linked indole carboxamides as a new scaffold for transmembrane H+/Cl− transport

Abstract

Herein, we introduced a series of carbonohydrazonoyl dicyanide-linked indole carboxamide 1a–1c transporters. Detailed mechanistic insight into the transport manifested that superior transporter 1a facilitates the movement of Cl− and H+/Cl− in a non-specific manner via the carrier mode. Geometrical optimization with the [1a + Cl−] complex provided an understanding of the Cl− ion binding process with the receptor 1a.