Cyanuryl peptide nucleic acid: synthesis and DNA complexation properties

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dc.contributor.authorVysabhattar, Ramanen_US
dc.contributor.authorGANESH, KRISHNA N.en_US
dc.contributor.departmentDept. of Chemistryen_US
dc.date.accessioned2020-10-13T09:55:43Z
dc.date.available2020-10-13T09:55:43Z
dc.date.issued2008-02en_US
dc.description.abstractThe synthesis of cyanuryl PNA monomer (CyaPNA) 6 was achieved by direct N-monoalkylation of cyanuric acid with N-(2-Boc-aminoethyl)-N′-(bromoacetyl)glycyl ethyl ester 4. Compound 6 was incorporated as a T-mimic into PNA oligomers and biophysical studies on their triplexes/duplex complexes with complementary DNA oligomers indicated unusual stabilization of PNA:DNA hybrids when the cyanuryl unit was located in the middle of the PNA oligomer.en_US
dc.identifier.citationTetrahedron Letters, 49(8), 1314-1318.en_US
dc.identifier.issn0040-4039en_US
dc.identifier.sourcetitleTetrahedron Lettersen_US
dc.identifier.urihttp://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/5124
dc.identifier.urihttps://doi.org/10.1016/j.tetlet.2007.12.095
dc.language.isoenen_US
dc.publication.originofpublisherForeignen_US
dc.publisherElsevier B.V.en_US
dc.subjectPNAen_US
dc.subjectCyanuryl PNAen_US
dc.subject2008en_US
dc.titleCyanuryl peptide nucleic acid: synthesis and DNA complexation propertiesen_US
dc.typeArticleen_US

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