Isolation and Characterization of Bioactive Benzofuran Sesquiterpene from Marine Sponge Ircinia Fusca (Carter, 1880)

Abstract

A novel benzofuran sesquiterpene derivative:7-methyl-7-((E)-4-methylpenta1,3-dien-1-yl)-5,6,7,7a-tetrahydrobenzofuran-3a(4H)-ol(Iricinol A), was isolated from a marine sponge Ircinia fusca (Carter, 1880). The structure of the compound was elucidated by using 1D, 2DNMR, and ESI-MS-TOF. The compound showed broad-spectrum activity against bacteria and fungi at 2 µg/µL. Also, it exhibited in vitro cytotoxic activity against RAW264.7 cells (mouse monotype macrophage leukemia) and N2A cells (neuroblastoma) with IC50 values 55 ± 4.21 µg/mL.