Synthesis and evaluation of hypervalent Iodine compounds as antibacterials

Abstract

In past two decades, there has been a global surge in the number of drug resistant pathogens. This can be accounted to the indiscriminate use of antibiotics. The increased global drug resistant bacterias pose a serious health hazard in upcoming decades while global pharmaceutical companies just try to maximise their profits. In this context, Diphenyleneiodonium chloride (DPIC) a known inhibitor of NADH/NADPH has been reported as a potent antibacterial molecule against M. Tb and S.aureus. Based on this fact a series of pyridine derivatives of DPI (PPI) compounds were synthesised and were evaluated against gram-negative and gram-positive bacteria. All the compounds exhibit strong antimicrobial activity against gram-negative, gram-positive bacteria. Diphenyl iodonium (DPI) has considerably less antibacterial activity against gram-negative bacteria compared to phenylpyridine iodonium (PPI) which showed very good antibacterial activity against gram-positive as well as gram-negative bacteria. PPI shows very promising antibacterial activity it has the potential of being an antibacterial agent.