In situ, on-resin synthesis of 8-Br/NH2 adeninyl peptide nucleic acid (PNA) oligomers and complementation studies with DNA

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2010-12

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Elsevier B.V.

Abstract

A new, novel and efficient in situ synthesis of 8-aminoadeninyl PNA oligomers from corresponding 8-bromoadeninyl PNA oligomers is reported. The study of hybridisation properties of (8-Br/8-NH2) PNA oligomers with cDNA reveals substitution-site dependent stabilization of derived triplexes and duplexes.

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Peptide nucleic acid, Medicinal chemistry, DNA and RNA, Pyrimidine PNA sequence, Trifluoromethane sulphonic acid, 2010

Citation

Tetrahedron Letters, Vol. 50(51).

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http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/1489
 https://doi.org/10.1016/j.tetlet.2010.10.040

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