miRNAs: early prognostic biomarkers for Type 2 diabetes mellitus?

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dc.contributor.authorBhatia, Parnikaen_US
dc.contributor.authorRaina, Shikhaen_US
dc.contributor.authorCHUGH, JEETENDERen_US
dc.contributor.authorSharma, Shilpyen_US
dc.contributor.departmentDept. of Chemistryen_US
dc.date.accessioned2019-03-15T11:22:37Z
dc.date.available2019-03-15T11:22:37Z
dc.date.issued2015-10en_US
dc.description.abstractType 2 diabetes mellitus (T2DM) has reached epidemic proportions and is associated with peripheral insulin resistance. The currently used therapies aim to delay progression of T2DM. Their efficacy could drastically be improved if implemented at earlier stages. Classical diagnostic markers (blood glucose and HbA1C) are generally detected once metabolic imbalance has already set in. Therefore, development of biomarkers for early diagnosis would help identify individuals at risk for developing T2DM. Along with genetic predisposition, epigenetics also plays a major role in T2DM development. In this review, we discuss the potential role of early diagnostic markers such as circulating miRNAs, studies done so far and challenges to be considered while taking into account the novel role of miRNAs as prognostic biomarkers.en_US
dc.identifier.citationBiomarkers in Medicine, 9(10), 1025-40.en_US
dc.identifier.issn1752-0363en_US
dc.identifier.sourcetitleBiomarkers in Medicineen_US
dc.identifier.urihttp://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/2142
dc.identifier.urihttps://doi.org/10.2217/bmm.15.69
dc.language.isoenen_US
dc.publication.originofpublisherForeignen_US
dc.publisherFuture Medicineen_US
dc.subjectbiomarkeren_US
dc.subjectHbA1Cen_US
dc.subjectmiRNAen_US
dc.subjectpancreatic ?-cellen_US
dc.subjectType 2 diabetes mellitusen_US
dc.subject2015en_US
dc.titlemiRNAs: early prognostic biomarkers for Type 2 diabetes mellitus?en_US
dc.typeArticleen_US

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