Peptides and Polypeptides Derived from 4S/R-(hyp/amp)-Proline: Synthesis and Characterisation of β-Structure

Abstract

The thesis entitled “Peptides and Polypeptides Derived from 4S/R-(hyp/amp)-Proline: Synthesis and Characterisation of β-structure’’ is comprised of studies towards the design and synthesis of peptides based on 4-substituted prolines in hybrid amides and polyproline and study of their conformational behavior under variable physical environments which may have importance in understanding their biological functions. The work describes different conformational behavior of 4-amino/hydroxy hybrid amides and polyproline peptides under different solute and solvent conditions and characterisation of β-structure.