Simulating the Parameter Sensitivity of the ‘Geometric Clutch’ Model of Ciliary Oscillations

Abstract

The axoneme is made of a large number of various components which makes it difficult to manipulate or alter it experimentally. A computational approach would be well-suited to understand the mechanism by which an axoneme self-regulates its oscillations. This report describes a simple simulation based on the ‘geometric clutch model’ which states that transverse forces can change inter-doublet distances and thus, regulate the dynein activity which is responsible for sliding of doublets and bending of the axoneme. Effects of varying the density of dynein motors, length of the axoneme, force per dynein motor, elastic constant of nexin and bending stiffness of the whole axoneme have also been described.