Biochemical characterization of CG15111 and CG1309, the fly orthologs of human ABHD12 and ABHD16A respectively

Abstract

PHARC is an autosomal recessive neurological disorder caused a null mutation in ABHD12 gene. The murine model for PHARC is kind of characterized but the other model organism like Drosophila is not well characterized. We here try to characterize the fly genes CG15111 and CG1309, the orthologues of ABHD12 and ABHD16A as the deregulation of the amount of lyso-PS will lead to PHARC pathology and these 2 genes regulates the amount of lyso-PS in mammalian brain. Here we have done initial step to characterize these genes and make a fly model for PHARC pathology and finding their effects in the fly immunity.