Structural Control of Peptide Nucleic Acid Rotamers: Aza-PNA and Optical Properties of Gemdimethyl PNA, Bimodal PNA Monomers and Oligomers

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dc.contributor.advisorGANESH, KRISHNA N.en_US
dc.contributor.authorSHIRAJ, ABDULen_US
dc.contributor.departmentDept. of Chemistryen_US
dc.contributor.registration20163469en_US
dc.date.accessioned2022-10-17T11:53:59Z
dc.date.available2022-10-17T11:53:59Z
dc.date.issued2022-06en_US
dc.descriptionThis chapter gives an overview of DNA/RNA duplex, triplex and tetraplex structure, chemically modified DNA and Peptide nucleic acid. Synthetically modified oligonucleotide (ODNs) of DNA and RNA are capable of forming Watson-Crick hydrogen bonded duplex between the two complementary strands as natural DNA. Polypyrimidine sequences of DNA/RNA oligomers are capable of forming triplexes by combination of Watson-crick and Hoogsteen hydrogen bonding among the three composed strands. The specificity in complementary base pairing to forming stable duplexes and triplexes make synthetic DNA an ideal candidate to suppress undesirable genes and is the basis of new medicinal chemistry concept of antigene and antisense therapy.en_US
dc.description.abstractThe thesis entitled “Structural control of Peptide Nucleic Acid (PNA) rotamers and their fluorescence properties: aza-PNA, gemdimethyl G-PNA and Cα(S)-bm PNA monomers and oligomers” describes studies done on the synthesis, characterisation and rotamer study of novel aza-PNA monomers, α/β-gemdimethyl guanine PNA, Cα(S)-(acetamido)-bm PNA monomers and oligomers. The effect of intramolecular H-bonding in Cα-NH (aza-PNA) and gem-dimethyl substitution induced conformational constraint on rotamer selectivity and the fluorescence properties are explored in this work. The thesis is presented in five chapters.en_US
dc.description.embargoone yearen_US
dc.description.sponsorshipCSIR , IISER-Puneen_US
dc.identifier.citation315en_US
dc.identifier.urihttp://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/7398
dc.language.isoenen_US
dc.subjectChemistryen_US
dc.titleStructural Control of Peptide Nucleic Acid Rotamers: Aza-PNA and Optical Properties of Gemdimethyl PNA, Bimodal PNA Monomers and Oligomersen_US
dc.typeThesisen_US
dc.type.degreePh.Den_US

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