Esterase Activated Carbonyl Sulfide/Hydrogen Sulfide (H2S) Donors

Simple item page
dc.contributor.authorChauhan, Preetien_US
dc.contributor.authorBORA, PRERONAen_US
dc.contributor.authorRAVIKUMAR, GOVINDANen_US
dc.contributor.authorJos, Swethaen_US
dc.contributor.authorCHAKRAPANI, HARINATHen_US
dc.contributor.departmentDept. of Chemistryen_US
dc.date.accessioned2019-07-01T05:33:18Z
dc.date.available2019-07-01T05:33:18Z
dc.date.issued2017-01en_US
dc.description.abstractHydrogen sulfide (H2S) is a mediator of a number of cellular processes, and modulating cellular levels of this gas has emerged as an important therapeutic area. Localized generation of H2S is thus very useful but highly challenging. Here, we report pivaloyloxymethyl-based carbonothioates and carbamothioates that are activated by the enzyme, esterase, to generate carbonyl sulfide (COS), which is hydrolyzed to H2S.en_US
dc.identifier.citationOrganic Letters, 19 (1), 62-65.en_US
dc.identifier.issn1523-7060en_US
dc.identifier.issn1523-7052en_US
dc.identifier.sourcetitleOrganic Lettersen_US
dc.identifier.urihttp://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/3209
dc.identifier.urihttps://doi.org/10.1021/acs.orglett.6b03336
dc.language.isoenen_US
dc.publication.originofpublisherForeignen_US
dc.publisherAmerican Chemical Societyen_US
dc.subjectEsterase Activated Carbonylen_US
dc.subjectSulfide (H2S) Donorsen_US
dc.subjectCarbonyl sulfide (COS)en_US
dc.subjectH2S donorsen_US
dc.subjectCOS/H2Sen_US
dc.subject2017en_US
dc.titleEsterase Activated Carbonyl Sulfide/Hydrogen Sulfide (H2S) Donorsen_US
dc.typeArticleen_US

Files

Collections

JOURNAL ARTICLES