Tailor-made Polysaccharide Vesicles for Drug Delivery to Cancer cells

Abstract

Design and development of polymer based controlled drug delivery systems has been emerging as important area of research for cancer treatment. Among the various challenges, delivering multiple anticancer drugs based on single polymer nano-carrier is particularly emerging as challenging task to enhance the tumor resistance to individual drug molecules and their therapeutic efficacies. Polymer vesicles (or polymersomes) are important classes of nano-carriers for delivering multiple drug loads such as hydrophilic and hydrophobic drugs together in a single dose. Polysaccharides are one of the most promising systems owing to their natural abundance, superior biodegradability and biocompatibility and so on so forth. However, structural optimizations in the hydrophilic polysaccharide with appropriate hydrophobic units are challenging task to produce polysaccharide vesicles. Thus, the polysaccharide vesicles for delivering multiple anticancer drugs (both hydrophilic and hydrophobic together) is less explored area in drug delivery research. The thesis is aimed to develop new polysaccharide vesicles that are stable for encapsulation and preservation of drugs to achieve better cancer treatment.