Bis(cholyl)-based chloride channels with oxalamide and hydrazide selectivity filters

Abstract

We report the development of supramolecular bis(cholyl) ion channels by using oxalamide and hydrazide as selectivity filters. The hydrazide system displayed superior chloride transport activity than oxalamide via the formation of a barrel stave channel. The better chloride recognition within the hydrazide channel over the oxalalmide was confirmed from the theoretical calculations.