Synthesis, thiol-mediated reactive oxygen species generation profiles and anti-proliferative activities of 2,3-epoxy-1,4-naphthoquinones

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dc.contributor.authorDHARMARAJA, ALLIMUTHU T.en_US
dc.contributor.authorDash, Tapan K.en_US
dc.contributor.authorKonkimalla, V. Badireenathen_US
dc.contributor.authorCHAKRAPANI, HARINATHen_US
dc.contributor.departmentDept. of Chemistryen_US
dc.date.accessioned2019-07-23T11:08:16Z
dc.date.available2019-07-23T11:08:16Z
dc.date.issued2012-01en_US
dc.description.abstractHere, we report that thiol-mediated decomposition of 2,3-epoxy-1,4-naphthoquinones to generate peroxide, a reactive oxygen species (ROS), could be modulated by changing the substitution pattern on the aryl ring and the epoxide. Epoxides which generated higher amounts of peroxide upon reaction with thiols were better inhibitors of human leukaemia (THP1) cell proliferation.en_US
dc.identifier.citationMedChemCommun, 3(2), 219-224.en_US
dc.identifier.issn2040-2503en_US
dc.identifier.issn2040-2511en_US
dc.identifier.sourcetitleMedChemCommunen_US
dc.identifier.urihttp://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/3604
dc.identifier.urihttps://doi.org/10.1039/C1MD00234A
dc.language.isoenen_US
dc.publication.originofpublisherForeignen_US
dc.publisherRoyal Society of Chemistryen_US
dc.subjectChemistryen_US
dc.subject2012en_US
dc.titleSynthesis, thiol-mediated reactive oxygen species generation profiles and anti-proliferative activities of 2,3-epoxy-1,4-naphthoquinonesen_US
dc.typeArticleen_US

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