Copper(I) iodide-DMAP catalyzed homo- and heterocoupling of terminal alkynes

Abstract

A practical and efficient catalytic system comprising CuI and DMAP has been developed for the oxidative homo- and heterocoupling of terminal alkynes under aerobic conditions at room temperature. The catalytic utility of DMAP for efficient oxidative coupling of terminal alkynes has been explored. The CuI-DMAP catalytic system avoids the need for excess base and specialized ligands in oxidative coupling. Short reaction times make this approach economical and environmentally friendly.