Anti-Mycobacterium Metabolite from Marine Sponge Iricinia fusca

Abstract

Chemical investigation of the marine sponge Ircinia fusca leads to isolation of a new pyrrole derivative (1) and two known compounds namely, 3 methyl decanoic acid (2) and Benzenedicarboxylic acid (3). The structures of compounds were established by 1D and 2D NMR and MS data. Compound 1 exhibited strong antibacterial activity against Mycobacterium smegmatis at MIC 116 ?M. Compounds 1-3 showed neither antifungal nor cytotoxic activity.