α/γ4-Hybrid peptide helices: synthesis, crystal conformations and analogy with the α-helix†

Abstract

Synthesis, crystal conformations of a/c4 -hybrid peptide helices containing proteinogenic amino acid side-chains, and the analogy with the a-helix are reported. Results suggest that a/c4 -hybrid peptides adopted helical conformations with 12-membered H-bond pseudocycles in single crystals