Structural Design and Synthesis of Bimodal PNA That Simultaneously Binds Two Complementary DNAs To Form Fused Double Duplexes

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dc.contributor.authorGUPTA, MANOJ KUMARen_US
dc.contributor.authorMadhanagopal, Bharath Rajen_US
dc.contributor.authorDATTA, DHRUBAJYOTIen_US
dc.contributor.authorGANESH, KRISHNA N.en_US
dc.contributor.departmentDept. of Chemistryen_US
dc.date.accessioned2020-07-31T06:38:10Z
dc.date.available2020-07-31T06:38:10Z
dc.date.issued2020-07en_US
dc.description.abstractBimodal PNAs are new PNA constructs designed to bind two different cDNA sequences synchronously to form double duplexes. They are synthesized on solid phase using sequential coupling and click reaction to introduce a second base in each monomer at Cα via alkyltriazole linker. The ternary bimodal PNA:DNA complexes show stability higher than that of individual duplexes. Bimodal PNAs are appropriate to create higher-order fused nucleic acid assemblies.en_US
dc.identifier.citationOrganic Letters, 22(13), 5255-5260.en_US
dc.identifier.issn1523-7060en_US
dc.identifier.issn1523-7052en_US
dc.identifier.sourcetitleOrganic Lettersen_US
dc.identifier.urihttp://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/4923
dc.identifier.urihttps://doi.org/10.1021/acs.orglett.0c01950
dc.language.isoenen_US
dc.publication.originofpublisherForeignen_US
dc.publisherAmerican Chemical Societyen_US
dc.subjectPeptide nucleic-acidsen_US
dc.subjectStrand displacementen_US
dc.subjectSequenceen_US
dc.subjectAnalogsen_US
dc.subjectThermodynamicsen_US
dc.subjectRecognitionen_US
dc.subjectCytosineen_US
dc.subjectThymineen_US
dc.subjectDna/Rnaen_US
dc.subjectFutureen_US
dc.subjectTOC-JUL-2020en_US
dc.subject2020en_US
dc.subject2020-JUL-WEEK5en_US
dc.titleStructural Design and Synthesis of Bimodal PNA That Simultaneously Binds Two Complementary DNAs To Form Fused Double Duplexesen_US
dc.typeArticleen_US

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