Hydrogen sulfide mediated cascade reaction forming an iminocoumarin: applications in fluorescent probe development and live-cell imaging

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dc.contributor.authorMISHRA, PRATRYUSH KUMARen_US
dc.contributor.authorSAHA, TANMOYen_US
dc.contributor.authorTALUKDAR, PINAKIen_US
dc.contributor.departmentDept. of Chemistryen_US
dc.date.accessioned2020-10-26T06:38:02Z
dc.date.available2020-10-26T06:38:02Z
dc.date.issued2015en_US
dc.description.abstractThe study on a fluorescent probe that undergoes a H2S mediated cascade reaction to form an imino-coumarin fluorophore is reported. The probe features better water solubility and fast sensing time (t(1/2) = 6.1 min and response time = 24 min) as key advances compared to the reported probe that works on a similar mechanism. The sensing mechanism of the probe was demonstrated by mass spectrometric, HPLC titration and FT-IR titration methods. H2S sensing by the probe was characterized by a 31-fold fluorescence enhancement and alimit of detection of 169 nM. Application of the probe was demonstrated by imaging of H2S in live cells.en_US
dc.identifier.citationOrganic & Biomolecular Chemistry, 13(27), 7430-7436.en_US
dc.identifier.issn1477-0520en_US
dc.identifier.issn1477-0539en_US
dc.identifier.sourcetitleOrganic & Biomolecular Chemistryen_US
dc.identifier.urihttp://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/5274
dc.identifier.urihttps://doi.org/10.1039/c5ob00785b
dc.language.isoenen_US
dc.publication.originofpublisherForeignen_US
dc.publisherRoyal Society of Chemistryen_US
dc.subjectLiving Cellsen_US
dc.subjectH2Sen_US
dc.subjectActivationen_US
dc.subjectKetonesen_US
dc.subject2015en_US
dc.titleHydrogen sulfide mediated cascade reaction forming an iminocoumarin: applications in fluorescent probe development and live-cell imagingen_US
dc.typeArticleen_US

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