Reverse Intramolecular Stacking in o‐Xylene Bridge Symmetrical Dimers of 2‐Thiopyridine Derivative: Assessment of the Conformational Stability

Abstract

Herein, we report o‐xylene based symmetrical dimers of 2‐thiopyridine derivative for studies of intramolecular stacking and conformational analysis 1‐3. The conformational analyses of all compounds have been carried out in solid, solution and gaseous states. Interestingly, all compounds showed reverse intramolecular stacked conformation between contiguous rings. Among all, compound 3 has shown polymorphism properties that also shown reverse intramolecular stacked conformation. The polymorphic studies have been achieved through single crystal X‐ray diffraction, intermolecular interactions in their crystal packing, overlay diagram, DSC analysis and Hirshfeld surface analysis.