A small molecule for theraNOstic targeting of cancer cells

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dc.contributor.authorRAVIKUMAR, GOVINDANen_US
dc.contributor.authorBagheri, Meisamen_US
dc.contributor.authorSaini, Deepak Kumaren_US
dc.contributor.authorCHAKRAPANI, HARINATHen_US
dc.contributor.departmentDept. of Chemistryen_US
dc.date.accessioned2019-07-01T05:33:18Z
dc.date.available2019-07-01T05:33:18Z
dc.date.issued2017-11en_US
dc.description.abstractThera/NO – a small molecule that is activated by hydrogen peroxide to generate nitric oxide (NO) and a fluorescence signal is reported. Using cancer and primary cells, we show that Thera/NO preferentially releases NO in cancer cells, which can trigger DNA damage and cell death in them. The coupled fluorescence signal facilitated tracking the NO release in living cells without collateral consumption of NO.en_US
dc.identifier.citationChemical Communications, 53(61), 8592-8595.en_US
dc.identifier.issn1359-7345en_US
dc.identifier.issn1364-548Xen_US
dc.identifier.sourcetitleChemical Communicationsen_US
dc.identifier.urihttp://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/3210
dc.identifier.urihttps://doi.org/10.1039/C7CC08526E
dc.language.isoenen_US
dc.publication.originofpublisherForeignen_US
dc.publisherRoyal Society of Chemistryen_US
dc.subjectSmall moleculeen_US
dc.subjecttheraNOstic targetingen_US
dc.subjectCancer cellsen_US
dc.subjectCytotoxic effect of compounden_US
dc.subjectFluorophoreen_US
dc.subjectFluorescence correspondingen_US
dc.subject2017en_US
dc.titleA small molecule for theraNOstic targeting of cancer cellsen_US
dc.typeArticleen_US

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