Strategies for the Diastereoselective Synthesis of Glycosides by Conformational Bias

Abstract

The thesis entitled “Strategies for the Diastereoselective Synthesis of Glycosides by Conformational Bias” is divided into five chapters. Chapter one demonstrates brief ideas about the importance of glycoconjugates and oligosaccharide and stereo-selective synthesis of glycoconjugates. Chapter two describes hypervalent iodine mediated stereo- and regioselective synthesis of C-2-deoxy glycosides and amino acid glycoconjugates. In chapter three, we have determined the influence of steric crowding on the diastereoselective arabinofuranosylation. In chapter four, we have exploited Reciprocal-Donor-Acceptor- Selectivity (RDAS) to assemble hencontapentasaccharide (51units) of mycobacterial Lipoarabinomannan. In chapter five, Reciprocal-Donor-Acceptor-Selectivity (RDAS) for the synthesis of four possible hybrid isomers of Araf-Ribf glycolipids at disaccharide and pentasaccharide level was described.