Effect of DNA Conformation on the Protein Search for Targets on DNA: A Theoretical Perspective

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dc.contributor.authorMONDAL, KINJALen_US
dc.contributor.authorCHAUDHURY, SRABANTIen_US
dc.contributor.departmentDept. of Chemistryen_US
dc.date.accessioned2020-05-22T13:07:13Z
dc.date.available2020-05-22T13:07:13Z
dc.date.issued2020-04en_US
dc.description.abstractProtein–DNA interactions are important for all biological processes and involve the process of proteins searching for and recognizing specific binding sites on the DNA. Many aspects of the mechanism of the protein search for targets on DNA are not well understood. One important problem is the effect of DNA conformation on the protein search dynamics. Using a theoretical method based on a discrete-state stochastic approach, we obtained an analytical description of the dynamic properties. We investigated a system with two DNA conformers. It was found that the average search time on one DNA conformer via 1D or 3D motions depended on the dynamics of the search process on the other DNA conformer.en_US
dc.identifier.citationJournal of Physical Chemistry B, 124(17), 3518-3526.en_US
dc.identifier.issn1520-6106en_US
dc.identifier.issn1520-5207en_US
dc.identifier.sourcetitleJournal of Physical Chemistry Ben_US
dc.identifier.urihttp://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/4608
dc.identifier.urihttps://doi.org/10.1021/acs.jpcb.0c01996
dc.language.isoenen_US
dc.publication.originofpublisherForeignen_US
dc.publisherAmerican Chemical Societyen_US
dc.subjectBinding Proteinsen_US
dc.subjectDynamicsen_US
dc.subjectDiffusionen_US
dc.subjectSiteen_US
dc.subjectTranscriptionen_US
dc.subject1Den_US
dc.subjectTOC-MAY-2020en_US
dc.subject2020en_US
dc.subject2020-MAY-WEEK3en_US
dc.titleEffect of DNA Conformation on the Protein Search for Targets on DNA: A Theoretical Perspectiveen_US
dc.typeArticleen_US

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