Design synthesis and biological evaluation of JNK1 inhibitors

dc.contributor.advisor	Venkata Palle	en_US
dc.contributor.advisor	BHAT, RAMAKRISHNA G.	en_US
dc.contributor.author	SHISHIR, CHOUREY	en_US
dc.contributor.department	Dept. of Chemistry	en_US
dc.contributor.registration	20061033	en_US
dc.date.accessioned	2011-05-18T12:11:19Z
dc.date.available	2011-05-18T12:11:19Z
dc.date.issued	2011-04	en_US
dc.description.abstract	c-Jun NH2-terminal kinase (JNK) is a stress activated protein kinase which modulate cellular signaling that is implicated in a variety of diseases like type-2 diabetes, cancer, atherosclerosis, stroke, Alzheimer’s and Parkinson diseases. JNK Interacting Protein 1 (JIP1) is a scaffolding protein of JNK which enhances JNK signaling by integrating the modules of JNK signaling. A part of the scaffolding protein- JIP-1 containing 153- 163 AA residues - known as pepJIP1 acts as an inhibitor to JNK at an allosteric site. The present work aims in design, synthesis and biological activity of small molecule allosteric inhibitors of JNK1.	en_US
dc.description.sponsorship	Lupin Limited (Research Park), Pune	en_US
dc.identifier.uri	http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/148
dc.language.iso	en	en_US
dc.publisher	IISER Pune	en_US
dc.subject	2011	en_US
dc.subject	Medicinal Chemistry	en_US
dc.title	Design synthesis and biological evaluation of JNK1 inhibitors	en_US
dc.type	Thesis	en_US
dc.type.degree	BS-MS	en_US

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